Obscurity test5/24/2023 Jepps and Dobell ( 65) considered the nucleus of D. This is reflected in a variety of descriptions conferred on the organism, such as: “a neglected cause of diarrhea” ( 49), “an unusual intestinal pathogen” ( 12), “an emerging protozoal infection” ( 129), and “an enigma shrouded in the mysteries of clinical parasitology” ( 140). Since the first description of Dientamoeba fragilis by Jepps and Dobell in 1918 ( 65) this ameboid organism has escaped the interest of most clinicians and diagnostic microbiologists. fragilis recently identified represent organisms with differing virulence. Also, it remains to be answered whether the two distinct genotypes of D. fragilis might be transmitted via the ova of the pinworm, Enterobius vermicularis. How the organism is transmitted remains a mystery, although there is some evidence that D. Analyses of small-subunit rRNA gene sequences have clearly demonstrated its close relationship to Histomonas, and it is now known to be a trichomonad. Significant progress has been made in the biological classification of this organism, which originally was described as an ameba. However, there are limitations in the use of cultures since they cannot be performed on fecal samples that have been fixed. fragilis is most commonly identified using permanently stained fecal smears, recent advances in culturing techniques are simplifying as well as improving the ability of investigators to detect this organism. ![]() fragilis as a cause of irritable bowel syndrome, allergic colitis, and diarrhea in human immunodeficiency virus patients. A number of studies have even incriminated D. ![]() There is little justification for this neglect, however, since there exists a growing body of case reports from numerous countries around the world that have linked this protozoal parasite to clinical manifestations such as diarrhea, abdominal pain, flatulence, and anorexia. ![]() Ever since its first description in 1918, Dientamoeba fragilis has struggled to gain recognition as a significant pathogen.
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